Stone formers, their spouses and first-degree relatives have been investigated for hypercalciuria and crystalluria. The incidence of hypercalciuria was far greater in stone-formers and their first-degree relatives than in their spouses. The urine of the stone-formers and their first-degree relatives contained calcium oxalate crystals in greater number and of larger size than that of the spouses or the controls. It was concluded that the predisposition to renal stone disease was far greater in those who shared the genetic pattern of stone-formers than those who shared their environmental conditions only.
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Marya et al. (2010) studied this question.