Key result
Unstable angina surges to ~25% of CAD discharges, warranting inclusion in primary prevention trials.
Why the study?
Trends in CAD mortality, incidence, and hospital discharges suggest that relying solely on AMI as a primary end point in prevention trials may not reflect current CAD presentation.
Design
Review of CAD primary end point definitions and epidemiologic trends
Authors
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Rising unstable angina hospitalizations merit surveillance; hypothesis-generating for its inclusion as primary endpoint in CAD prevention trials.
Given the rising incidence of unstable angina hospitalizations, it should be considered as a primary endpoint in future primary prevention trials for coronary artery disease.
Whitney et al. (1992) conducted a review in Coronary artery disease. Unstable angina discharges increased from 4% of CAD discharges in 1980 to 25% in 1989 in the U.S., suggesting it should be considered as a primary endpoint in future primary prevention trials.
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