Answers are grounded in this paper and cite their sources.
[figure: see text] An efficient strategy to construct the congested C-7a quaternary chiral center of anisatin was developed, by way of an Eschenmoser-Claisen rearrangement. Conversion of the resultant amide to Kende's epsilon-lactone intermediate 3 in four steps completed a concise formal synthesis of (+/-)-8-deoxyanisatin (2).
No takes yet. Share an insight, caveat, or question.
Loh et al. (2000) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: