The protective effects of taurine on hyperlipidemia associated with puromycin aminonucleoside-induced nephrotis were assessed in male Wistar rats. Administration of puromycin aminonucleoside to rats resulted in hyperlipidemia at the end of 10 days, as indicated by significant elevation of cholesterol, triglycerides, and phospholipids in plasma and liver. A significant increase in plasma lipid peroxides associated with lipoprotein fractions was observed in nephrotic rats. Liver lipids and lipid peroxides were also higher in these animals. On the other hand, reduced lipoprotein lipase activity was noted in liver of the puromycin-treated rats. In addition, urinary excretion of cholesterol was also high in them. However, treatment of the nephrotic rats with taurine modified hyperlipidemia with reduction in lipid peroxide and all major lipoprotein fractions. Taurine significantly prevented the decrease in lipoprotein lipase activity induced by puromycin. Therefore, our results suggest that prevention of hyperlipidemia by taurine contributes to its therapeutic effects in attenuating the puromycin-induced nephrotic syndrome.
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Venkatesan et al. (1993) studied this question.
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