Solutions of pea‐leaf acetone‐dried powder oxidise [1‐14C]palmitic acid to 14CO2, and oxidise [14C16]palmitic acid to 14CO2]pentadecanoic acid and [14C]myristic acid. If d‐2‐hydroxy[12C]‐palmitic acid is also present, these metabolites are slightly less radioactive; if l‐2‐hydroxy[12C]‐palmitic acid is also present, the metabolites are much less radioactive. It is concluded that the sequential α‐oxidation of long‐chain fatty acids involves the l‐2‐hydroxyacid preferentially, thus: RCH2CO2H→l‐RCHOHCO2H→RCO2H→etc.
No takes yet. Share an insight, caveat, or question.
Hitchcock et al. (1968) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: