Azabicyclo[3.1.0]hexane‐1‐carbohydrazides as Potent and Selective GHSR1a Ligands Presenting a Specific in vivo Behavior

Buon appetito! The synthesis and in vitro and in vivo profiles of a novel series of potent and selective ghrelin ligands is presented. Selected compounds share the same “atypical” ghrelin antagonist profile already observed with the recently disclosed compound GSK1614343, thus exhibiting the same ability to promote food intake and body weight gain in rodents.