Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation

Histone modifications regulate many fundamental biological processes, including DNA replication, transcription, and repair. Eighteen posttranslational modifications of histones, including acetylation, succinylation, and methylation, have been reported 1 , 2 , 3 . Lysine acetyltransferase 2A (KAT2A, also known as GCN5), a member of the GCN5-related N-acetyltransferase superfamily and a component of Spt-Ada-KAT2A-acetyltransferase (SAGA) and Ada-two-A-containing complexes, was identified as the first transcription-related histone acetyltransferase in 1996 4 , 5 . KAT2A binds to acetyl-coenzyme A (CoA) and transfers its acetyl group to histones to regulate chromatin architecture and locus-specific transcription 6 .