Key result
Mouse lineage tracking reveals <50% of brown adipocytes derive from the central dermomyotome.
Why the study?
The embryonic origin of distinct fat depots and the role of ontogeny in specifying functional differences among adipocyte lineages is unclear.
Adipocyte lineage cells' behavior in response to a high fat diet is not strictly determined by their developmental history, despite distinct embryonic origins.
Mouse data indicate brown adipocyte diet responses are not lineage-determined; leaves open human cardiometabolic relevance.
The embryonic origin of distinct fat depots and the role for ontogeny in specifying the functional differences among adipocyte lineages between and within depots is unclear. Using a Cre/Lox-based strategy to track the fate of major mesodermal subcompartments in mice we present evidence that <50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation, and that perigonadal adipocytes arise from separate mesodermal subcompartments in males and females. Last, we show adipocyte precursors (APs) of distinct lineages within the same depot exhibit indistinguishable responses to a high fat diet, indicating that ontogenetic differences between APs do not necessarily correspond to functional differences in this context. Altogether, these findings shed light on adipose tissue patterning and suggest that the behavior of adipocyte lineage cells is not strictly determined by developmental history.
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Sebo et al. (2018) studied Adipose tissue development. Cre/Lox-based lineage tracking and high fat diet was evaluated on Adipocyte lineage origin and response to high fat diet. Cre/Lox-based lineage tracking in mice showed that <50% of interscapular brown adipocytes derive from the central dermomyotome and distinct lineages respond similarly to a high fat diet.
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