Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies

Nadav Furie; Michal Mandelboim; Neta S. Zuckerman; Ana Belkin; Lior Seluk; Inbal Shafran; Ronen Mass; Liran Levy; Sumit Chatterji; Erik Baltaxe; Michael Peled; Tiberiu Shulimzon; Abraham Avigdor; Sharon Amit; Amir Onn; Edith M. Marom; Galia Rahav; Michael Segel

doi:10.1093/ofid/ofad464

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Abstract

We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

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Furie et al. (2023) studied this question.

synapsesocial.com/papers/6aa957a4f8b27f8ac662fc36 https://doi.org/10.1093/ofid/ofad464

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Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies

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Abstract

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Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies

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Abstract

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