A semiempirical study of pyrazole acylhydrazones as potential antimalarial agents

In this work, we evaluated structural and electronic similarities between a new class of acylhydrazones, recently presented as effective inhibitors of a Plasmodium falciparum cysteine protease, and a series of pyrazole arylacylhydrazones with analgesic and antiaggregating (antithrombotic) properties, using AM1. The calculated results suggest that at least one of the pyrazole compounds is similar enough to the active compounds to be considered as a candidate for a future antimalarial series.