Key result
Accessory renal artery linked to ~63% higher direct renin and elevated 24-hour blood pressure.
Why the study?
The association between accessory renal artery and hypertension remains not fully understood.
Does the presence of an accessory renal artery affect blood pressure and renin concentration in middle-aged patients with primary hypertension?
Cross-Sectional (n=162)
Does the presence of an accessory renal artery affect blood pressure and renin concentration in middle-aged patients with primary hypertension?
Absolute Event Rate: 18.24% vs 11.21%
p-value: p=0.002
The presence of an accessory renal artery in middle-aged patients with primary hypertension is associated with higher direct renin concentrations and elevated blood pressure, suggesting it may contribute to hypertension and target organ damage.
Does not warrant screening changes in hypertension; leaves open accessory renal artery contribution to renin and BP elevation.
Objectives . The association between accessory renal artery (ARA) and hypertension remains not fully understood. We observed the association between ARA and clinical characteristics among middle‐aged patients with primary hypertension. Methods . One hundred and sixty‐two middle‐aged (mean 39.82 ± 10.25 years, 58.0% male) patients with primary hypertension were enrolled, and patients underwent Computed Tomography Angiography (CTA) of renal arteries, ambulatory blood pressure monitor (ABPM), echocardiography, physical examination, and routine blood chemistry examinations. According to the CTA results, patients were divided into a non‐ARA ( n = 108) and ARA ( n = 54) group. Direct renin concentration (DRC), plasma aldosterone concentration (PAC), ABPM, echocardiography, creatinine, and glomerular filtration rate were compared between the two groups. Results . DRC (mU/L) (11.21 (5.34, 20.87) vs. 18.24 (10.32, 33.59), P = 0.002) was significantly higher in the ARA group than in the non‐ARA group. However, PAC (ng/dL) (98.30 (67.30, 134.00) vs. 116.50 (78.80, 137.25), P = 0.103) was similar between these two groups. ABPM (mmHg) results showed that daytime (146.75 ± 17.04/95.86 ± 11.39 vs. 155.50 ± 14.76/100.48 ± 10.69, P < 0.05), night time (133.44 ± 17.50/85.28 ± 12.80 vs. 139.81 ± 14.64/89.83 ± 11.21, P < 0.05), and 24 h blood pressure (143.95 ± 15.99/93.90 ± 11.78 vs. 152.07 ± 13.85/98.11 ± 10.36, P < 0.05) were significantly higher in the ARA group than in the non‐ARA group. Accordingly, echocardiographic‐derived posterior left ventricular wall thickness value was higher in the ARA group than in the non‐ARA group. Conclusion . ARA is related to higher blood pressure and higher direct renin concentration in middle‐aged patients with primary hypertension, and these patients deserve stricter blood pressure control. Our results provide important evidence for that ARA is a cause of hypertension and target organs damages.
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Kang et al. (2020) conducted a cross-sectional in Primary hypertension (n=162). Accessory renal artery (ARA) vs. Non-accessory renal artery (non-ARA) was evaluated on Direct renin concentration (mU/L) (p=0.002). In middle-aged patients with primary hypertension, an accessory renal artery was associated with higher direct renin concentration (18.24 vs 11.21 mU/L; P=0.002) and higher 24-hour blood pressure.
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