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Sweets for my sweet: The production and isolation of 5-hydroxymethylfurfural (HMF) in high yield and purity is demonstrated by using a combination of glucose-fructose isomerization with sweetzyme in wet tetraethylammonium bromide (TEAB) and clean fructose dehydration to HMF catalyzed by using HNO₃ under moderate conditions, which allow the reuse of any unreacted glucose and TEAB.
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Simeonov et al. (2013) studied this question.
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