The 1H NMR spectral parameters of prostaglandin F1α (5c), prostaglandin F1β (5a), 8-epi-prostaglandin F1α (5b), and derivatives are discussed. Evidence is presented for the occurrence of a restricted number of conformations in the three series. The solvent-dependent variation of the 1H NMR spectral parameters of prostaglandin F1α is interpreted on the basis of intramolecular hydrogen bonding between the 9- and 11-hydroxyl groups.
No takes yet. Share an insight, caveat, or question.
Clercq et al. (1977) studied this question.