What question did this study set out to answer?

To emphasize the scientific value of investigating obesity-related genetic variants in highly consanguineous populations to uncover novel molecular pathways underlying the disease.

January 10, 2019EBioMedicineOpen Access

Genetics of obesity in consanguineous populations – A road map to provide novel insights in the molecular basis and management of obesity

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Authors

NKNitin KapoorBaker Heart and Diabetes Institute ACAaron ChaplaChristian Medical College, Vellore JFJohn FurlerThe University of Melbourne

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Implication

Scientific commentary highlights the utility of genetic analyses in consanguineous populations, suggesting unique pathways to uncover the molecular pathogenesis of obesity.

Key Points

To emphasize the scientific value of investigating obesity-related genetic variants in highly consanguineous populations to uncover novel molecular pathways underlying the disease.
Synthesized findings from recent genome-wide association studies regarding key determinants of body composition, including Irx3.
Evaluated the methodological value of mapping obesity-related genetic architecture within consanguineous cohorts.
Highlights that consanguineous cohorts provide heightened detection power for identifying rare, recessive genetic variants governing body mass index and composition.
Proposes an exploratory roadmap utilizing population-specific genetic architectures to inform targeted therapeutic management of obesity.

Cite This Study

Kapoor et al. (2019) studied this question.

synapsesocial.com/papers/6aa95ac82a3e17c169263aaa https://doi.org/10.1016/j.ebiom.2019.01.004

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Implication

Scientific commentary highlights the utility of genetic analyses in consanguineous populations, suggesting unique pathways to uncover the molecular pathogenesis of obesity.

Genetics of obesity in consanguineous populations – A road map to provide novel insights in the molecular basis and management of obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

Genetics of obesity in consanguineous populations – A road map to provide novel insights in the molecular basis and management of obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

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