Key result
Lewis antigen positivity linked to all rotavirus infections regardless of secretor status.
Why the study?
The relationship between rotavirus infections and secretor status in children with gastroenteritis was unclear.
Cross-Sectional (n=114)
No
P[8] rotavirus can infect both secretors and nonsecretors, with infection correlating with the presence of Lewis antigen.
Answers are grounded in this paper and cite their sources.
Lewis antigen positivity was associated with rotavirus infection independent of secretor status; hypothesis-generating and requires prospective confirmation before clinical implications.
To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis.We phenotyped saliva for human blood group antigens and tested feces for rotavirus.Rotavirus was detected in 32/114 patients.Secretor genotyping showed that P[8] rotavirus infected secretors and nonsecretors, and infection correlated with presence of Lewis antigen.
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Ayouni et al. (2015) conducted a cross-sectional in Acute gastroenteritis (n=114). Lewis antigen and secretor phenotypes vs. Lewis antigen-negative and nonsecretor phenotypes was evaluated on Rotavirus infection (p=0.017). Rotavirus infections, including genotype P[8], occurred in both secretor and nonsecretor patients but were observed exclusively in Lewis antigen-positive individuals (p=0.017).
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