Key result
Chinese, Japanese, and Filipinos show lower VTE risk compared to Whites and South Asians.
Why the study?
Although a lower risk of venous thromboembolism in Asians compared to Whites has been suggested, data for specific Asian American ethnic groups remain sparse due to prior small sample sizes.
Does the risk of venous thromboembolism vary among specific Asian American ethnic groups compared to Whites?
Observational (n=61,459)
Does the risk of venous thromboembolism vary among specific Asian American ethnic groups compared to Whites?
The risk of venous thromboembolism is lower in Chinese, Japanese, and Filipino populations compared to Whites and South Asians, suggesting a genetic basis for VTE risk disparities.
Hypothesis-generating for ethnicity-specific VTE risk models in Asian Americans; prospective validation required before clinical adoption.
Lower risk of venous thromboembolism in Asians compared to Whites has been suggested. Despite the biological and cultural diversity of Asian Americans, data are sparse for specific ethnic groups. In our prior study of lower Asian American risk, the small number of subjects (337 in all races) precluded accurate study of specific Asian American groups. We present here a new study with 4674 venous thromboembolism subjects diagnosed between 1996 and 2015. Our study population was derived from 61,459 voluntary health examinees in a comprehensive northern California health plan with self-classified ethnicity: 53.0% Whites, 28.4% Blacks, 11.6% ASAMs, 6.8% Others. Of Asian Americans, 44.7% were Chinese, 32.8% Filipinos, 12.9% Japanese, 4.5% South Asians, and 5.0% Other Asians. Chinese, Japanese, Filipinos, and Other Asians each had lower venous thromboembolism risk than both Whites and South Asians, who had risk similar to each other. These data indirectly support a genetic explanation.
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Tran et al. (2019) conducted an observational in Venous thromboembolism (n=61,459). Asian ethnicity (Chinese, Japanese, Filipinos, South Asians, Other Asians) vs. Whites was evaluated on Venous thromboembolism. Chinese, Japanese, Filipinos, and Other Asians each had a lower risk of venous thromboembolism than both Whites and South Asians, who had similar risks to each other.
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