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In vitro study demonstrates human milk fractions inhibit DAEC and EAEC adherence to HeLa cells, indicating protective benefits of breast milk components against infant diarrheal pathogens.
Binding to a specific receptor is an essential step for most enteropathogens to initiate an intestinal infection. We analyzed the inhibitory effect of human milk and its protein components on adhesion of two diarrheagenic Escherichia coli strains, diffusely adherent E. coli (DAEC) and enteroaggregative E. coli (EAEC), to HeLa cells. Defatted milk, whey proteins, immunoglobulin and non-immunoglobulin fractions, in concentrations lower than usually found in whole milk, inhibited both DAEC and EAEC adhesion, indicating that human milk components may contribute to the defense of the infants against enteropathogens.
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Loreny Gimenes Giugliano (2000) studied this question.
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