Key result
LEPR 223R allele linked to ~170% greater obesity risk in females on atypical antipsychotics.
Why the study?
Weight gain is a serious adverse effect of atypical antipsychotic agents and genetic factors influencing this risk are not fully understood.
Do LEPR, LEP, and HTR2C polymorphisms predict obesity and BMI change in patients using atypical antipsychotic medication?
Cohort (n=141)
Do LEPR, LEP, and HTR2C polymorphisms predict obesity and BMI change in patients using atypical antipsychotic medication?
The LEPR Q223R polymorphism may be a risk factor for obesity in women treated with atypical antipsychotic drugs.
Answers are grounded in this paper and cite their sources.
LEPR 223R may flag obesity risk in women on atypical antipsychotics; leaves open prospective validation and extension to BMI trajectories.
UNLABELLED: Weight gain is a frequently occurring serious somatic adverse effect of atypical antipsychotic agents. Genetic factors influence the risk of an individual to gain weight. OBJECTIVES: To determine whether LEPR Q223R, LEP -2548G/A and HTR2C -759C/T polymorphisms are associated with obesity and weight change in patients using atypical antipsychotic drugs. METHODS: A longitudinal study design was used in a naturalistic setting. The study population included 141 patients, all of whom were using an atypical antipsychotic drug. The body mass index was measured twice. Primary outcome measures were obesity at the moment of first measurement and body mass index change during treatment. Determinants were the LEPR Q223R (rs1137101), the LEP -2548G/A SNP (rs7799039) and the HTR2C -759C/T (rs3813929) polymorphisms. RESULTS: Of the 141 included patients, 35 (24.8%) were obese. In females, presence of the LEPR 223R allele was associated with an increased risk of obesity (47.6 vs 17.6%; p = 0.03). In males this association was not found. None of the SNPs were significantly associated with weight change during treatment. CONCLUSIONS: The LEPR Q223R polymorphism may be a risk factor for obesity in women with a psychotic disorder treated with atypical antipsychotic drugs. This is in line with earlier findings of our group.
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Gregoor et al. (2011) conducted a cohort in Psychotic disorder (n=141). LEPR 223R allele vs. Absence of LEPR 223R allele was evaluated on Obesity at first measurement (p=0.03). The LEPR 223R allele was associated with an increased risk of obesity in females using atypical antipsychotic drugs (47.6% vs 17.6%; p=0.03).
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