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Murine models fail to predict the cytotoxic T-lymphocyte responses to AAV capsids observed in humans, highlighting fundamental differences in how human and murine hepatocytes process and present AAV antigens. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Immune Responses to AAV Capsid: Are Mice Not Humans After All?

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