Key result
Calcium chelation by EGTA eliminates rotavirus VP7 neutralizing epitopes, which excess calcium or strontium restores.
Calcium chelation induces a conformational change in rotavirus VP7, suggesting it binds calcium independently and may mediate uncoating of double-shelled particles.
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Calcium chelation alters VP7 epitopes in vitro; leaves open any role in rotavirus uncoating or therapeutic targeting.
Dormitzer et al. (1992) studied Rotavirus. Calcium chelation by EGTA vs. Addition of excess calcium or strontium was evaluated on Conformational change and loss of neutralizing epitopes in VP7. Calcium chelation by EGTA induced a conformational change in rotavirus VP7 that eliminated neutralizing epitopes, which was restored by adding excess calcium or strontium.
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