The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

Q: What does this research mean for the field?

The gain-of-function TREM2-T96K mutation increases the risk for Alzheimer's disease by impairing microglial function in a sex-dependent manner. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Dominika Piłat; Hoang Le; Dmitry Prokopenko; Chih‐Chung Lin; William A. Eimer; Luisa Quinti; Evan P. Gavrilles; Sara N Heitman; D. McGinty; Murat Çetinbaş; Ruslan I. Sadreyev; Rudolph E. Tanzi; Ana Griciuc

doi:10.1016/j.neuron.2025.09.032

October 17, 2025NeuronOpen Access

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

View Full Paper

Ask AI

Bookmark

Share

Key Points

To investigate how the gain-of-function TREM2-T96K mutation alters microglial function and drives an increased risk for Alzheimer’s disease.
Examined the molecular and functional consequences of the TREM2-T96K gain-of-function mutation in microglial models.
Assessed microglial phenotypic responses and functional deficits across male and female biological contexts.
The gain-of-function TREM2-T96K mutation significantly diminishes normal microglial activity.
Adverse effects of the TREM2-T96K variant on microglial function manifest in a sex-dependent manner to increase Alzheimer's disease risk.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Laboratory study demonstrates microglial function impairment by TREM2-T96K across sexes, suggesting a biological mechanism for heightened Alzheimer’s risk.

Abstract

adversely affects microglial function in a sex-dependent manner.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Piłat et al. (2025) studied this question.

synapsesocial.com/papers/6aa95d6510c8139d8e8796f7 https://doi.org/10.1016/j.neuron.2025.09.032

View Full Paper

Ask AI

Bookmark

Share

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading