Rainbow trout (Salmo gairdneri) peripheral blood lymphocytes and splenocytes were found to have spontaneous cytotoxic activity against cultured mammalian and fish tumor cell lines. P 815 and YAC 1 target cells were found to be highly sensitive to trout natural killer (NK) cell lysis, while K 562 and ML cells were low and EL 4 was resistant. NK cell activity was not significantly altered by a 12-mo dietary exposure of fish to various concentrations of Aroclor 1254 and/or mirex.
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Cleland et al. (1987) studied this question.