Key result
Abnormal electrograms in the middle right atrium predict a ~7-fold higher risk of chronic AF.
Why the study?
Electrophysiologic abnormalities that predict the transition from idiopathic paroxysmal atrial fibrillation to chronic atrial fibrillation have not been established.
Does the presence of abnormal atrial electrograms in the middle right atrium predict the development of chronic atrial fibrillation in patients with idiopathic paroxysmal atrial fibrillation?
Cohort (n=96)
Does the presence of abnormal atrial electrograms in the middle right atrium predict the development of chronic atrial fibrillation in patients with idiopathic paroxysmal atrial fibrillation?
p-value: p=<0.0001
Extended distribution of abnormal atrial electrograms from the high to middle right atrium strongly predicts the progression from paroxysmal to chronic atrial fibrillation.
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Abnormal middle-RA electrograms were associated with CAF progression in idiopathic PAF; leaves open whether mapping-guided therapy alters risk.
Nakao et al. (2002) conducted a cohort in Idiopathic paroxysmal atrial fibrillation (n=96). Abnormal atrial electrograms in the middle right atrium vs. Absence of abnormal atrial electrograms in the middle right atrium was evaluated on Development of chronic atrial fibrillation (CAF) (p=<0.0001). Abnormal atrial electrograms in the middle right atrium predicted the development of chronic atrial fibrillation over 10 years (>50% vs 7% in patients without these abnormalities; P<0.0001).