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Clonidine, an alpha-adrenoceptor agonist, reduces human plasma melatonin levels when administered intravenously at 2-3 micrograms kg-1 to sleeping volunteers. Measurement of plasma melatonin levels after administration of clonidine could be the basis for a clinical in-vivo test of alpha-adrenoceptors.
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Lewy et al. (1986) studied this question.
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