Straightforward and label-free: A simple method for the detection of histone-modifying enzymes is based on quantum dot (QD) Förster resonance energy transfer (FRET) donors. Histone acetyltransferase activity can be measured via the enzyme-dependent assembly of a quantum dot/peptide immunocomplex (see picture; His=histidine), which can be conducted in a homogeneous reaction without the need for complicated surface derivatization procedures.
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Ghadiali et al. (2011) studied this question.
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