Hypercoagulable state in three dogs with nephrotic syndrome: Role of acquired antithrombin III deficiency

SUMMARY The hypercoagulable state accompanying nephrotic syndrome in 3 dogs was characterized by markedly increased fibrinogen and factor VIII concentrations. Antithrombin III was mildly reduced in 1 dog (74% of normal) and markedly reduced in the other 2 dogs (48% and 32% of normal). In the dog with the most severe antithrombin III deficiency, pulmonary thrombosis was a prominent clinical problem, ultimately leading to the dog's death.