Key result
Postoperative H-FABP predicts clinical outcomes no better than CK-MB, Troponin-I, or bypass times.
Why the study?
Early identification of vulnerable pediatric cardiac surgery patients is important, and the predictive value of heart-type fatty acid-binding protein (H-FABP) for clinical outcomes after surgery is unclear.
Does postoperative H-FABP predict clinical outcomes better than CK-MB, troponin-I, or bypass times in pediatric patients undergoing ventricular septal defect closure?
Observational (n=32)
Does postoperative H-FABP predict clinical outcomes better than CK-MB, troponin-I, or bypass times in pediatric patients undergoing ventricular septal defect closure?
H-FABP does not offer stronger predictive value for clinical outcomes than standard biomarkers like CK-MB or troponin-I after pediatric cardiac surgery.
Answers are grounded in this paper and cite their sources.
H-FABP offers no predictive advantage over CK-MB or troponin-I after pediatric VSD closure; leaves open whether novel biomarkers improve risk stratification.
INTRODUCTION: The early identification of vulnerable pediatric cardiac surgery patients can help clinicians provide them with timely support. Heart-type fatty acid-binding protein. (H-FABP) is an early biomarker of myocardial injury in acute myocardial infarction in adults. In this study, we evaluated the correlations between postoperative H-FABP, creatine kinase-myocardial band (CK-MB), troponin-I, total bypass time, and clinical outcomes. METHODS: In 32 pediatric patients that underwent ventricular septal defect. closure we measured H-FABP, troponin-I and CK-MB preoperatively and 1, 3, and 6 h after aortic declamping. Spearman's Rho correlations were calculated between laboratory and clinical parameters including inotropic support duration, aortic cross-clamp time, total bypass time, ventilation-weaning-time, and total Intensive Care Unit stay. RESULTS: H-FABP, CK-MB, troponin-I, and total bypass time have a similarly weak to moderate correlation with clinical outcome measures. CONCLUSIONS: The predictive value of H-FABP for clinical outcome is not stronger than that of CK-MB, Troponin-I, or bypass times.
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Vanagt et al. (2017) conducted an observational in ventricular septal defect (n=32). Postoperative H-FABP vs. CK-MB, Troponin-I, and total bypass time was evaluated on clinical outcomes including inotropic support duration, ventilation-weaning-time, and total Intensive Care Unit stay.
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