The stereoselective total synthesis of methyl (3R,4S,5S,6R)-6-chloro-3,4,5-trihydroxy-1-cyclohex-1-enecarboxylate (1), which had been reported as the antitumour marine natural product pericosine A, from (−)-quinic acid was achieved. From the total synthesis, it was confirmed that the reported stereostructure of pericosine A was incorrect because the spectroscopic data of the synthetic product were not identical with those of the natural compound.
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Usami et al. (2005) studied this question.
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