Key result
Pre-transplant overweight and obesity do not affect post-transplant physical quality of life in kidney recipients.
Why the study?
Overweight and obesity impair health-related quality of life in patients with chronic illnesses, but their effects on post-transplant physical HRQOL in kidney transplant recipients are unclear.
Does pre-transplant overweight and obesity affect post-transplant physical quality of life in kidney transplant recipients?
Cohort (n=464)
No
Does pre-transplant overweight and obesity affect post-transplant physical quality of life in kidney transplant recipients?
p-value: p=>=0.112
Pre-transplant overweight and obesity do not negatively impact physical quality of life after kidney transplantation.
Pretransplant overweight or obesity need not limit transplant candidacy on HRQOL grounds; extends survival data but leaves open need for prospective confirmation.
BACKGROUND: Recent studies demonstrate that obesity does not affect survival after kidney transplantation. However, overweight and obesity impair health-related quality of life (HRQOL) in patients with chronic illnesses. We wished to examine the effects of pre-transplant overweight and obesity on post-transplant physical HRQOL in kidney transplant recipients. STUDY DESIGN: Patient-reported HRQOL data were systematically collected in kidney transplant recipients receiving post-transplant follow-up at Vanderbilt Transplant Center. Patients who received kidney transplants between 1998 and 2008, had at least 1 post-transplant physical component summary (PCS) measurement, and did not receive other solid organ transplants were included in this retrospective cohort study. Pre-transplant body mass index was stratified as normal, overweight, obese class I, and obese class II/extremely obese. HRQOL was measured primarily with the PCS scale of the Medical Outcomes Study Short Form 36 Health Survey. Multivariate linear and logistic regression models were used to test the effects of body mass index and demographic and clinical covariates on post-transplant HRQOL. RESULTS: The study cohort included 464 adults (mean body mass index 27.5 +/- 5.1; range 18.5 to 47.4). After controlling for gender (p = 0.148), pre-transplant dialysis (p = 0.003), previous kidney transplantation (p = 0.255), donor type (p = 0.455), steroid avoidance immunosuppression (p = 0.070), and follow-up time (p = 0.352), there was no effect of pre-transplant overweight or obesity on post-transplant PCS (all p > or = 0.112). Kidney transplant recipients who did not require dialysis pre-transplant and those who were managed with steroid avoidance after transplantation were more likely to achieve post-transplant PCS scores at or above the general population average (both p < or = 0.011). CONCLUSIONS: Pre-transplant overweight and obesity do not affect physical quality of life after kidney transplantation.
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Zaydfudim et al. (2010) conducted a cohort in Kidney transplantation (n=464). Pre-transplant overweight and obesity vs. Normal pre-transplant body mass index was evaluated on Post-transplant physical component summary (PCS) score (p=>=0.112). Pre-transplant overweight and obesity did not significantly affect post-transplant physical quality of life in kidney transplant recipients (all P>=0.112).
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