To the Editor: An association between membranous nephropathy and malignant tumors has been known for decades. 1 It was hypothesized that circulating, preformed immune complexes containing tumor antigens deposit in the glom-eruli and induce membranous nephropathy; however, this hypothesis no longer appears to explain how subepithelial immune deposition occurs. 2 The in situ binding of antibodies to endogenous antigens, which is strongly supportedThe New England
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Hoxha et al. (2016) studied this question.
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