A laminated shell microcapsule is described resisting aggregation and withstanding ultrasound destruction, showing a good backscatter signal, as shown in the figure. Templated synthesis produces versatile monodisperse capsules <3 µm, with ultrasound-pressure dependency allowing rupture above MI ∼ 1.5 (at 2 MHz), suitable for future development as both controlled-delivery agent and contrast agent.
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Lin et al. (2009) studied this question.
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