A copper‐catalyzed formylation reaction has been developed by employing oxygen (O2) as the clean oxidant. The CH bonds of indoles were C‐3‐formylated by tetramethylethylenediamine (TMEDA) and water (H2O; in situ formed and external added water) as the carbonyl source in moderate to good yields with good functional group tolerance. Thus, it represents a facile procedure leading to 3‐formylindoles.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: