Key result
MRAI improves spatial definition of major arteries vs pulse coherence maps without a pulse reference.
Why the study?
Magnetic resonance advection imaging maps may provide improved spatial definition of cerebrovascular pulse dynamics without the need for a pulse reference, but their potential significance and application require demonstration.
Does magnetic resonance advection imaging improve spatial definition of cerebrovascular pulse dynamics compared to pulse coherence maps in healthy subjects?
Cross-Sectional (n=19)
Does magnetic resonance advection imaging improve spatial definition of cerebrovascular pulse dynamics compared to pulse coherence maps in healthy subjects?
Magnetic resonance advection imaging can visualize cerebrovascular pulse dynamics and major arteries with better spatial definition than pulse coherence maps, without needing a pulse reference.
May aid cerebrovascular research with reference-free arterial mapping; leaves open clinical translation pending patient validation.
We analyze the pulsatile signal component of dynamic echo planar imaging data from the brain by modeling the dependence between local temporal and spatial signal variability. The resulting magnetic resonance advection imaging maps depict the location of major arteries. Color direction maps allow for visualization of the direction of blood vessels. The potential significance of magnetic resonance advection imaging maps is demonstrated on a functional magnetic resonance imaging data set of 19 healthy subjects. A comparison with the here introduced pulse coherence maps, in which the echo planar imaging signal is correlated with a cardiac pulse signal, shows that the magnetic resonance advection imaging approach results in a better spatial definition without the need for a pulse reference. In addition, it is shown that magnetic resonance advection imaging velocities can be estimates of pulse wave velocities if certain requirements are met, which are specified. Although for this application magnetic resonance advection imaging velocities are not quantitative estimates of pulse wave velocities, they clearly depict local pulsatile dynamics. Magnetic resonance advection imaging can be applied to existing dynamic echo planar imaging data sets with sufficient spatiotemporal resolution. It is discussed whether magnetic resonance advection imaging might have the potential to evolve into a biomarker for the health of the cerebrovascular system.
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Voss et al. (2016) conducted a cross-sectional in Healthy subjects (n=19). Magnetic resonance advection imaging vs. Pulse coherence maps was evaluated on Spatial definition of major arteries and local pulsatile dynamics. Magnetic resonance advection imaging provided better spatial definition of major arteries compared to pulse coherence maps without needing a pulse reference.
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