Treatment of lymphosarcoma with fractionated total body irradiation

A series of patients with disseminated lymphosarcoma has been treated with fractionated total body irradiation. The majority of patients experienced excellent objective remissions of disease as indicated by 75 to 100% decrease in the size of the measurable tumor lesions. No gastro-intestinal, neurologic or other constitutional symptoms resulted from irradiation and the hematopoietic toxicity was minimal. The encouraging initial responses observed and the absence of serious side effects suggest this modality of therapy constitutes a potentially useful tool in the treatment of this disease.