Key result
Rare glandular cardiac myxoma contains mucinous glands requiring careful distinction from secondary adenocarcinoma.
Why the study?
Glandular cardiac myxomas are extremely rare and their pathogenesis is unknown, requiring recognition to avoid misdiagnosis as secondary adenocarcinoma.
Case Report (n=1)
Glandular cardiac myxoma is a rare variant of cardiac myxoma that requires careful immunohistochemical evaluation to differentiate from secondary adenocarcinoma.
Adds rare glandular cardiac myxoma case to literature; leaves open pathogenesis and management questions.
Cardiac myxoma is the most common primary neoplasm of the heart and arises from the endocardium as a polypoid mass, which is commonly seen in the left atrium. Glandular cardiac myxomas are extremely rare cardiac myxomas that contain glandular structures and the pathogenesis of the glandular differentiation is unknown. The present case study reports a case of glandular cardiac myxoma. The tumor was located in the left atrium without invasion of the myocardium. Microscopically, the myxoma contained well-formed mucinous glands in a background of classic cardiac myxoma. Immunohistochemically, the mucinous glandular cells were strongly positive for cytokeratin 7 (CK7) and partially positive for calretinin, but negative for CD34, CK20, D2-40, WT-1, and TTF-1. In conclusion, glandular cardiac myxoma is very rare and it is important to recognize this entity correctly so that it is not misinterpreted as secondary adenocarcinoma.
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Wang et al. (2016) conducted a case report in Glandular cardiac myxoma (n=1). Glandular cardiac myxoma was evaluated on Histological and immunohistochemical characteristics. A rare case of glandular cardiac myxoma contained well-formed mucinous glands positive for CK7 and partially positive for calretinin, highlighting the need to distinguish it from secondary adenocarcinoma.
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