Key result
Imagent improves inter-reader agreement in segmental wall motion scores by ~67% vs noncontrast imaging.
Why the study?
The ability of the new echocardiographic contrast agent Imagent to improve endocardial border delineation and segmental wall motion assessment was evaluated due to suboptimal baseline imaging.
Does perflexane lipid microspheres improve endocardial border delineation and segmental wall motion assessment in patients with suboptimal baseline echocardiograms?
RCT (n=409)
Blinded readers
Randomized
Yes
Does perflexane lipid microspheres improve endocardial border delineation and segmental wall motion assessment in patients with suboptimal baseline echocardiograms?
Absolute Event Rate: 65% vs 39%
p-value: p=<0.0001
The use of perflexane lipid microspheres significantly improves endocardial border delineation and the accuracy of segmental wall motion assessment in patients with suboptimal baseline echocardiograms.
No takes yet. Share an insight, caveat, or question.
May enhance consistency of wall motion assessment; leaves open effects on clinical decisions and outcomes.
Nanda et al. (2003) conducted an RCT in Suboptimal baseline echocardiographic images (n=409). Imagent (perflexane lipid microspheres) vs. Saline / noncontrast imaging was evaluated on Inter-reader agreement in segmental wall motion (SWM) scores (Study A) (p=<0.0001). Imagent administration significantly improved inter-reader agreement in segmental wall motion scores compared to noncontrast imaging (65% vs 39% in Study A; P<0.0001).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: