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Evolutionary analysis reveals the broad distribution of poxviral entry-fusion complex proteins across giant viruses, suggesting a shared mechanism for host membrane penetration.
Fusion between virus and host membranes is critical for viruses to release genetic materials and to initiate infection. Whereas most viruses use a single protein for membrane fusion, poxviruses employ a multiprotein entry-fusion complex (EFC).
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Kao et al. (2023) studied this question.
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