Experimental study reveals that ZHX2 activates ELOVL3 to suppress cell cycle progression in liver models, suggesting a key mechanism linking lipid metabolism to liver regeneration.
Numerous targets of the transcription factor Zhx2 are dysregulated in liver disease. We show that the elongase Elovl3 is a novel Zhx2 target. Elovl3 and Zhx2 expression change during liver regeneration, which is associated with changes in very long chain fatty acids. Forced Elovl3 expression reduces cell growth and blocks cell cycle progression. This suggests that Elovl3 may account, at least in part, for the relationship between Zhx2 and proliferation during liver development and disease.
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Creasy et al. (2023) studied this question.
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