Key result
Post-MI new-onset AF ≥7 hours is linked to ~104% higher 7-year mortality versus <7 hours.
Why the study?
The relation between the duration of new-onset atrial fibrillation following acute myocardial infarction and long-term mortality was evaluated.
Does new-onset atrial fibrillation duration ≥ 7 hours predict higher mortality in patients following acute myocardial infarction compared to duration < 7 hours?
Cohort (n=320)
Does new-onset atrial fibrillation duration ≥ 7 hours predict higher mortality in patients following acute myocardial infarction compared to duration < 7 hours?
Relative Risk: 2.04 (95% CI 1.39–2.99)
Absolute Event Rate: 67.4% vs 34.4%
p-value: p=0.0002
New-onset atrial fibrillation lasting 7 hours or more following an acute myocardial infarction is an independent predictor of increased long-term mortality.
AF duration may refine post-AMI mortality risk stratification; leaves open whether it identifies modifiable targets or merely marks sicker patients.
AIM: The duration of new-onset atrial fibrillation (AF) following the acute myocardial infarction (AMI) was evaluated as well as its relation to in-hospital and 7-year mortality. METHODS AND RESULTS: A total of 320 consecutive patients with AF following AMI were examined and patients with AF <7 h (n = 141) were compared to those with AF > or =7 h in duration (n = 179). Receiver Operating Characteristic analysis was performed to identify the most useful AF duration cut-off level for the prediction of poor outcome. Patients with longer AF duration were older and had more advanced heart failure than patients with short arrhythmia duration. Patients with longer AF duration had worse outcome, including higher in-hospital (22.3 vs. 12.8%) and 7-year (67.4 vs. 34.4%) mortality. After multivariate adjustment, longer AF duration remained an independent predictor of long-term mortality (relative risk = 2.04, 95% confidence interval = 1.39-2.99, p = 0.0002). CONCLUSION: New-onset AF > or =7 h in duration following the AMI independently predicts long-term mortality.
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Ašanin et al. (2006) conducted a cohort in New-onset atrial fibrillation following acute myocardial infarction (n=320). New-onset atrial fibrillation ≥7 hours vs. New-onset atrial fibrillation <7 hours was evaluated on 7-year mortality (RR 2.04, 95% CI 1.39-2.99, p=0.0002). New-onset atrial fibrillation lasting ≥7 hours following acute myocardial infarction independently predicted higher 7-year mortality compared to <7 hours (RR 2.04; 95% CI 1.39-2.99; p=0.0002).