Experimental study demonstrates rapid mechanochemical deracemization of a paclobutrazol precursor via abrasive grinding, indicating a greener and more efficient route to enantiopure compounds.
We report the first case of mechanochemical deracemization by using liquid-assisted abrasive grinding. The target molecule is a precursor of Paclobutrazol, an important fungicide and plant growth inhibitor. Using mechanochemical deracemization, we are even able to transform a 10 % ee scalemic mixture of this latter in an enantioenriched product of 97 % ee in a couple of hours. This is substantially shorter compared to solution-based deracemization methodologies. The present paper thus introduces an efficient and greener process to enantiopure material.
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Lopes et al. (2023) studied this question.
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