Key result
Single Nucleotide Polymorphisms did not reach genome-wide significance for association with postoperative venous thromboembolism, though the top candidate rs505922 showed potential relevance (p=3.33×10−7).
Why the study?
Postoperative venous thromboembolism events constitute a major source of morbidity and mortality after surgery, prompting investigation into whether commonly occurring single nucleotide polymorphisms are associated with these events.
Are commonly occurring Single Nucleotide Polymorphisms (SNPs) associated with postoperative venous thromboembolism (VTE) in surgical patients?
Cohort (n=140,831)
Are commonly occurring Single Nucleotide Polymorphisms (SNPs) associated with postoperative venous thromboembolism (VTE) in surgical patients?
No single nucleotide polymorphisms reached genome-wide significance for association with postoperative VTE, though the ABO gene rs505922 showed relevance in the general cohort.
No genome-wide SNP associations with postoperative VTE; hypothesis-generating for rs505922 and should not yet change practice.
Postoperative Venous Thromboembolism Events (VTE) constitute a major source of morbidity and mortality after surgery. The aim of this study was to investigate whether commonly occurring Single Nucleotide Polymorphisms (SNPs) are associated with VTE in the surgical setting. Retrospective study using data from the United Kingdom (UK) biobank, a genome biobank containing healthcare and genotyping data from more than 500.000 individuals. A cohort of 140,831patients with a registered surgical procedure was identified and used for a discovery genome wide association study (GWAS), with the remainder of the cohort (305,349 non-surgical patients) used as a replication cohort. Primary outcome was associations between SNPs and VTE within 30 days after a surgical procedure. Genome wide significance was set at p = 5 × 10−8. In the surgical (discovery) cohort, no SNPs reached genome wide significance. The VTE association of the top candidate SNP in the ABO gene rs505922 (p = 3.33 × 10−7), was replicated in the general (replication) cohort (p = 2.42 × 10−59). and Relevance: This study did not identify associations between SNPs and postoperative VTE events reaching genome-wide significance, although the VTE relevance of top candidates were demonstrated.
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Christensen et al. (2021) conducted a cohort in Postoperative Venous Thromboembolism (n=140,831). Single Nucleotide Polymorphisms (SNPs) was evaluated on Associations between SNPs and VTE within 30 days after a surgical procedure (p=3.33 × 10−7). Single Nucleotide Polymorphisms did not reach genome-wide significance for association with postoperative venous thromboembolism, though the top candidate rs505922 showed potential relevance (p=3.33×10−7).
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