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January 1, 1983British Medical Bulletin

Pharmacological Interactions Between Prostacyclin and Thromboxanes

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Key result

Prostacyclin and thromboxane interactions drive opposing effects on vascular tone and platelet aggregation.

Authors

BWB J R WHITFLEWellcome TrustSalvador MoncadaSalvador MoncadaUniversity College Dublin

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Implication

May inform selective antithrombotic strategies; leaves open prospective clinical validation before practice change.

Key Points

Key points are not available for this paper at this time.

Cite This Study

WHITFLE et al. (1983) studied this question. Pharmacological interactions between prostacyclin and thromboxanes mediate critical opposing effects on vascular tone and platelet aggregation.

synapsesocial.com/papers/6aa9fe4c71e43eb1ac55823ahttps://doi.org/10.1093/oxfordjournals.bmb.a071825
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.1987 · 111 citations
  2. 2Prostacyclin, Thromboxane A 2 Interactions in Haemostasis and Thrombosis2009 · 34 citations
  3. 3Development of Dual-Acting Benzofurans for Thromboxane A2 Receptor Antagonist and Prostacyclin Receptor Agonist: Synthesis, Structure−Activity Relationship, and Evaluation of Benzofuran Derivatives2005 · 38 citations
  4. 4A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis2007 · 63 citations
  5. 5The biochemical pharmacology of thromboxane synthase inhibition in man.1985 · 123 citations