Key result
Primary tumour volume >371 cm3 is linked to a ~103% increase in lung metastasis.
Why the study?
The association between tumour volume and occurrence of lung metastasis in patients with osteosarcoma was not well defined.
Is primary tumour volume associated with the occurrence of lung metastasis in patients with osteosarcoma?
Observational (n=70)
Is primary tumour volume associated with the occurrence of lung metastasis in patients with osteosarcoma?
Larger primary tumour volume (>371 cm3) in osteosarcoma is significantly associated with a higher likelihood of lung metastasis.
Larger tumour volume was associated with lung metastasis in osteosarcoma; leaves open whether volume thresholds aid staging or prognosis.
PURPOSE: To assess the association between tumour volume and occurrence of lung metastasis in patients with osteosarcoma and to determine the cut-off value. METHODS: Records of 70 patients with histopathologically confirmed primary osteosarcoma in the extremities who had magnetic resonance imaging and computed tomography of the thorax less than one month before treatment were reviewed, with reference to the official report of tumour dimensions and lung metastasis by radiologists. The status of lung metastasis was assessed. Tumour volume was measured using the formula for an ellipsoidal mass. RESULTS: Of the 70 patients with osteosarcoma, 33 (47%) had evidence of lung metastasis. Tumour volume was directly associated with occurrence of lung metastasis (p=0.048). The proportion having lung metastasis when the primary tumour volume exceeded 371 cm3 was 69%, compared to 34% in those with smaller tumours. CONCLUSION: Larger tumours are more likely to correlate with lung metastasis. Both features are predictive of patient survival and prognosis.
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Munajat et al. (2008) conducted an observational in Primary osteosarcoma in the extremities (n=70). Primary tumour volume > 371 cm3 vs. Primary tumour volume ≤ 371 cm3 was evaluated on Occurrence of lung metastasis (p=0.048). Primary tumour volume exceeding 371 cm3 was associated with a higher rate of lung metastasis compared to smaller tumours (69% vs 34%; p=0.048).
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