The center of attention: IscS cysteine desulfurases and IscU scaffolds are involved in biological iron–sulfur cluster assembly. The X-ray structure of an anaerobically produced, mutated (Fe2S2-(IscS-IscUD35A))2 complex reveals a cluster coordinated by three IscU cysteines and the IscS active cysteine (see picture). In air-exposed crystals the cluster is oxidized to an Fe2S–S center; D35 is essential for complex dissociation.
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Marinoni et al. (2012) studied this question.
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