The Vortex Fluidic Device is a flow reactor that processes reactions in thin films. Running the metal-free azide-alkyne cycloaddition in this reactor revealed a dramatic enhancement of the "on water" effect. For the copper-catalyzed azide-alkyne cycloaddition, stainless steel or copper jet feeds were effective reservoirs of active copper catalyst.
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Oksdath‐Mansilla et al. (2020) studied this question.
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