Key result
Adenosine potentiates insulin action in diabetic rat adipocytes, indicating preserved cellular response despite diabetes.
Why the study?
The impact of streptozotocin-induced diabetes on the response of adipocytes to adenosine effects in glucose oxidation was unclear.
Caution against clinical use in diabetes; leaves open adenosine-insulin synergy for in vivo investigation.
Streptozotocin-induced diabetes did not impair the response of adipocytes to adenosine effects in glucose oxidation. The greatest effect of adenosine in potentiating the action of insulin was in the physiological concentration range of insulin (10-100 mu units/ml). The desensitization of cells by diabetes to the effects of insulin is therefore probably not related to the response of cells to adenosine.
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Wong et al. (1985) studied Streptozotocin-induced diabetes. Adenosine was evaluated on Glucose oxidation of adipocytes. Adenosine potentiated the action of insulin in adipocytes from streptozotocin-diabetic rats, indicating that diabetes does not impair the cellular response to adenosine.
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