Key result
IV alteplase linked to sudden death in acute stroke with asymptomatic aortic dissection.
Why the study?
Cerebral infarction can occur in aortic dissection, and intravenous thrombolysis may be administered without paying sufficient attention to asymptomatic aortic dissection.
Case Report (n=1)
Intravenous thrombolysis with alteplase in patients with acute cerebral infarction and unrecognized asymptomatic aortic dissection can lead to lethal outcomes, highlighting the critical importance of recognizing aortic dissection prior to treatment.
Answers are grounded in this paper and cite their sources.
Thrombolysis risks sudden death in unrecognized aortic dissection; leaves open whether routine screening improves safety in stroke.
Background: Cerebral infarction may occur in patients with aortic dissection. Some neurologists gave intravenous thrombolysis for cerebral infarction without paying more attention to asymptomatic aortic dissection. Methods/Results: We report the case of a 66-year-old female presenting with unconsciousness who was admitted to our hospital. During intravenous thrombolysis (IVT) with alteplase(rt-PA), the patient died suddenly. One-stop skull and neck CT scan was reviewed during the discussion of the death case, asymptomatic aortic dissection was found. Conclusion:IVT with rt-PA in patient with acute cerebral infarction and asymptomatic aortic dissection may lead to lethal outcomes. Although uncommon, recognition of aortic dissection in patient with acute cerebral infarction is important.
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Bangxing Yu (2023) conducted a case report in Acute cerebral infarction and asymptomatic aortic dissection (n=1). Alteplase (rt-PA) was evaluated on Mortality. Intravenous thrombolysis with alteplase in a patient with acute cerebral infarction and asymptomatic aortic dissection led to sudden death.
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