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In a porcine model of refractory cardiac arrest treated with extracorporeal cardiopulmonary resuscitation (ECPR), mild hypercapnia increases cerebral glucose concentrations and reduces caspase-8 expression, but does not significantly improve brain tissue oxygen tension or other neurobiomarkers compared to normocapnia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Effects of systemic mild hypercapnia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation

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