Mixed salivary fluoride levels have been measured after 9 subjects sucked or slowly dissolved three different brands of 1 mg F–– fluoride tablets. Results indicate that for all preparations the maximum salivary F–– concentration was obtained when a tablet was sucked rather than dissolved. However, salivary F–– retention was greatly enhanced under conditions which allowed undisturbed disintegration of each formulation. The most highly flavoured tablet produced the least favourable data and it is postulated that the ideal clinical situation would be provided by a slightly flavoured tablet which would be capable of providing prolonged release of fluoride to the oral environment.
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McCall et al. (2009) studied this question.