High Resolution Image Download MS PowerPoint Slide Macrocyclic peptides containing C(sp 2 )–C(sp 3 ) side chain cross-links are a rapidly growing subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs), with significant potential in the development of new pharmaceuticals. This report presents a method for the efficient synthesis of derivatives of this class using a diastereoselective cross-electrophile coupling for the formation of the key β-aryl-alkyl cross-link.
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Plouch et al. (2025) studied this question.
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